NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (NDUFS3)

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (NDUFS3) is a core subunit of mitochondrial respiratory chain Complex I (NADH:ubiquinone oxidoreductase)[6][2][3][1]. It functions in electron transfer from NADH to ubiquinone, which is central to generating the proton gradient used for ATP synthesis through oxidative phosphorylation. NDUFS3 is essential for both the catalytic activity and the assembly of Complex I[3][6][4]. Mutations in this gene are associated with mitochondrial complex I deficiency and Leigh syndrome, showing its critical role in cellular energy metabolism and health[2][4][5]. It has emerging links to cancer cell proliferation via its role in glucose metabolism and mitochondrial function[4]. No drugs directly target NDUFS3 for therapy, but impairment can influence response to mitochondrial toxins and may serve as a diagnostic or disease-monitoring biomarker in select contexts.

Other names

NADH:ubiquinone oxidoreductase core subunit S3NDUFS3CI-30kDCI-30Complex I-30kDComplex I 30kDa subunitNADH-ubiquinone oxidoreductase 30 kDa subunitNADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDaNADH-coenzyme Q reductase

Electron transfer from NADH to ubiquinone in the mitochondrial respiratory chain (drugs targeting this process would affect ATP generation and mitochondrial function) Modulation by redox-active or mitochondrial-targeted drugs, if any (specific clinical modulators not established)